Extracellular traps released by antimicrobial TH17 cells contribute to host defense
نویسندگان
چکیده
منابع مشابه
Precarious balance: Th17 cells in host defense.
Lineage-specific responses from the effector T-cell repertoire form a critical component of adaptive immunity. The recent identification of Th17 cells-a third, distinct lineage of helper T cells-collapses the long-accepted paradigm in which Th1 and Th2 cells distinctly mediate cellular and humoral immunity, respectively. In this minireview, we discuss the involvement of the Th17 lineage during ...
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BACKGROUND Neutrophil extracellular traps (NETs) are a central player in the host response to bacteria: neutrophils release extracellular DNA (nucleosomes) and neutrophil elastase to entrap and kill bacteria. We studied the role of NETs in Burkholderia pseudomallei infection (melioidosis), an important cause of Gram-negative sepsis in Southeast Asia. METHODS In a prospective observational stu...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2021
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci141594